Trifluoroacetic acid → HCID 67486978, compound

Participants

Reaction Steps

tert-Butyl 3-(5-(5-(2-methoxy-2-oxoethylthio)-3-(2-methylpyridin-3-yloxy)pyridin-2-ylamino)-1,2,4-thiadiazol-3-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate (461 mg, 0.770 mmol) was dissolved in CH2Cl2 (10 mL) and TFA (5 mL) was added. The reaction was stirred at ambient temperature for 15 minutes. The reaction was partitioned between CH2Cl2 and saturated aqueous NaHCO3, dried over sodium sulfate, filtered and concentrated to afford methyl 2-(6-(3-(8-azabicyclo[3.2.1]octan-3-yl)-1,2,4-thiadiazol-5-ylamino)-5-(2-methylpyridin-3-yloxy)pyridin-3-ylthio)acetate (402 mg, 0.806 mmol, 105% yield) as a pale yellow foam.

Provenance & Evidence