Acetic Anhydride → HCID 67486976, compound

Participants

Reaction Steps

Methyl 2-(6-(3-(8-azabicyclo[3.2.1]octan-3-yl)-1,2,4-thiadiazol-5-ylamino)-5-(2-methylpyridin-3-yloxy)pyridin-3-ylthio)acetate (384 mg, 0.770 mmol) was dissolved in CH2Cl2 (7 mL), and triethylamine (16 μL, 1.16 mmol) and acetic anhydride (87.4 μL, 0.924 mmol) were added. The reaction was stirred at ambient temperature for 5 minutes. The reaction was partitioned between CH2Cl2 and saturated aqueous NaHCO3, dried over sodium sulfate, filtered and concentrated to afford methyl 2-(6-(3-(8-acetyl-8-azabicyclo[3.2.1]octan-3-yl)-1,2,4-thiadiazol-5-ylamino)-5-(2-methylpyridin-3-yloxy)pyridin-3-ylthio)acetate (397 mg, 0.734 mmol, 95.3% yield).

Provenance & Evidence