HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Tert-butyl 4-(hydroxymethyl)azepane-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Sulfate | HCID 24436 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | 1-tert-Butyl 4-ethyl azepane-1,4-dicarboxylate | HCID 66751951 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Tert-butyl 4-(hydroxymethyl)azepane-1-carboxylate | HCID 68708706 | 101.8% |
Reaction Steps
1-tert-Butyl 4-ethyl azepane-1,4-dicarboxylate (3.3 g, 12 mmol, US Publication No. 2006/229289) was dissolved in THF (100 mL) and cooled in an ice bath. LiAlH4 (12 mL, 12 mmol) was added slowly and stirred for 30 minutes. Water (˜3 mL) was added slowly, followed by Na2SO4. The reaction was filtered and concentrated to afford crude tert-butyl 4-(hydroxymethyl)azepane-1-carboxylate (2.8 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08362037B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-b9a0e17844934d85a86779cdebcd2eea |
| Source note | uspto-grants-2013_01 |