反应详情

A flask was charged with 3-(benzyloxy)-2-hydrazinylpyridine (10.0 g, 46.5 mmol) and triethoxymethane (77.3 ml, 465 mmol). The mixture was heated at reflux for 1 hour and then stirred overnight at ambient temperature. The solids were filtered and rinsed with EtOH and dried on high vacuum to afford 8-(benzyloxy)-[1,2,4]triazolo[4,3-a]pyridine (8.05 g, 35.7 mmol, 76% yield).

1. temperatureThe mixture was heated
2. temperatureat reflux for 1 hour
3. filtrationThe solids were filtered
4. washrinsed with EtOH
5. customdried on high vacuum