反应详情

To a 8-(benzyloxy)-[1,2,4]triazolo[4,3-a]pyridine (8.05 g, 35.7 mmol) dissolved in EtOH 100 ml was added 300 mg 10% Pd/C (Degussa). The reaction vessel was inerted with nitrogen and then purged with hydrogen 3 times, and the reaction was stirred under double balloon pressure of hydrogen overnight. The catalyst was removed by filtration and the filtrate concentrated to give a residue of [1,2,4]triazolo[4,3-a]pyridin-8-ol (4.23 g, 87% yield) that was used in the next step without further purification.

1. custompurged with hydrogen 3 times
2. customThe catalyst was removed by filtration
3. concentrationthe filtrate concentrated