Sulfuric Acid → HCID 67485983, compound

HRID 1809650Notes

Reaction equation

HRID 1809650 reaction equation
[CH3:1][C:2]1[C:7]([O:8][C:9]2[C:10]([C:22]#[N:23])=[N:11][CH:12]=[C:13]([S:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=3)[CH:14]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.S(=O)(=O)(O)[OH:25]>>[CH3:1][C:2]1[C:7]([O:8][C:9]2[C:10]([C:22]([NH2:23])=[O:25])=[N:11][CH:12]=[C:13]([S:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=3)[CH:14]=2)=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 67485792HCID 67485792, compound

Product 1

HCID 67485983HCID 67485983, compoundYield 95.6%

Procedure

Following the procedure in Example 51, Step E, and using 3-(2-methylpyridin-3-yloxy)-5-(pyridin-2-ylthio)picolinonitrile (60.8 g, 190 mmol) and sulfuric acid (350 mL) provided 3-(2-methylpyridin-3-yloxy)-5-(pyridin-2-ylthio)picolinamide (61.4 g, 181 mmol, 95.6% yield).

Sources & evidence

ORD record
ord-715ad7340a2d4dcab1d02281249de220
Source dataset
uspto-grants-2013_01
Patent number
US08362037B2

Reaction notes

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