Dimethylcarbamoyl Chloride → N,N-dimethyl-4-(5-(3-(2-methylpyridin-3-yloxy)-5-(pyridin-2-ylthio)pyridin-2-ylamino)-1,2,4-thiadiazol-3-yl)piperidine-1-carboxamide hydrochloride

Participants

Reaction Steps

Following the procedure in Example 1, Step G, and using N-(3-(2-methylpyridin-3-yloxy)-5-(pyridin-2-ylthio)pyridin-2-yl)-3-(piperidin-4-yl)-1,2,4-thiadiazol-5-amine (150 mg, 0.3141 mmol) and dimethylcarbamic chloride (33.77 mg, 0.3141 mmol) provided N,N-dimethyl-4-(5-(3-(2-methylpyridin-3-yloxy)-5-(pyridin-2-ylthio)pyridin-2-ylamino)-1,2,4-thiadiazol-3-yl)piperidine-1-carboxamide hydrochloride (145.2 mg, 0.2481 mmol, 79.01% yield). Mass spectrum (apci) m/z=549.1 (M+H—HCl).

Provenance & Evidence