Triethylamine → [3-(2-methylsulfanyl-pyrimidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-(2-morpholin-4-yl-ethyl)-amine

Participants

Reaction Steps

To a solution of 6-chloro-3-(2-methylsulfanyl-pyrimidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidine (from Example 7 supra) (2 g, 7.19 mmol) in 2-propanol (100 mL) was added 2-morpholinoethanamine (1.0 g, 7.9 mmol) followed by triethylamine (800 mg, 7.9 mmol). The reaction mixture was stirred with heating at reflux for 6 hours. The solvent was then removed under reduced pressure. The residue was washed with 2-propanol and water to afford [3-(2-methylsulfanyl-pyrimidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-(2-morpholin-4-yl-ethyl)-amine. (Yield 2.1 g, 80%).

Provenance & Evidence