反应详情

To a mixture of [3-(6-benzylamino-pyridin-2-yl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-(2-piperidin-1-yl-ethyl)-amine (133 mg, 0.24 mmol) in dichloromethane (2 mL) was added CF3CO2H (3 mL). This mixture was stirred at room temperature for 3 hours. The reaction was quenched by adding saturated aqueous NaHCO3 to pH about 9, and then extracted with dichloromethane (3×20 mL). The combined organic phase was dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. The residue was washed with EtOAc (4 mL) and dried to give [3-(6-benzylamino-pyridin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-(2-piperidin-1-yl-ethyl)-amine as a white solid. (Yield 78 mg, 76%).

1. customThe reaction was quenched
2. additionby adding saturated aqueous NaHCO3 to pH about 9
3. extractionextracted with dichloromethane (3×20 mL)
4. dry with materialThe combined organic phase was dried over anhydrous MgSO4
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure
7. washThe residue was washed with EtOAc (4 mL)
8. customdried