Trifluoroacetic acid → HCID 178420328, compound

Participants

Reaction Steps

To a stirred solution of a mixture of [3-(3-benzylamino-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-(2-morpholin-4-yl-ethyl)-amine and (2-morpholin-4-yl-ethyl)-[3-phenyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-amine (210 mg, crude) in dichloromethane (5 mL) was added TFA (5 mL) at room temperature. The resulting mixture was stirred for another three hours at this temperature. The solvent was evaporated under reduced pressure and the residue was treated with saturated aqueous NaHCO3 (3 mL) and extracted with EtOAc (10 mL). The organic phase was washed with brine (5 mL) and dried to give crude product. It was purified by prep-HPLC to give [3-(3-benzylamino-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-(2-morpholin-4-yl-ethyl)-amine as yellow solid. (Yield 24 mg, 14.9%).

Provenance & Evidence