HCID 178452782, compound → HCID 178507721, compound

Participants

Reaction Steps

To a solution of [4-(3-{2-[(thiophen-3-ylmethyl)-amino]-pyrimidin-4-yl}-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)-cyclohexyl]-carbamic acid tert-butyl ester (24 mg, 0.046 mmol) in methanol (30 mL) was bubbled in HCl (gas) for 3 hours at room temperature. The mixture was then concentrated by evaporation to afford N-(3-{2-[(thiophen-3-ylmethyl)-amino]-pyrimidin-4-yl}-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-cyclohexane-1,4-diamine; hydrochloride. (Yield 25 mg, 96%).

Provenance & Evidence