tert-butyl N-(2-amino-2-phenylethyl)carbamate → HCID 178453677, compound

HRID 1809773Notes

Reaction equation

HRID 1809773 reaction equation
CS([C:5]1[N:10]=[C:9]([C:11]2[C:19]3[C:14](=[N:15][C:16]([NH:20][CH2:21][CH2:22][N:23]4[CH2:28][CH2:27][O:26][CH2:25][CH2:24]4)=[N:17][CH:18]=3)[NH:13][N:12]=2)[CH:8]=[CH:7][N:6]=1)(=O)=O.[C:29]([O:33][C:34](=[O:45])[NH:35][CH2:36][CH:37]([NH2:44])[C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)([CH3:32])([CH3:31])[CH3:30]>>[C:29]([O:33][C:34](=[O:45])[NH:35][CH2:36][CH:37]([NH:44][C:5]1[N:10]=[C:9]([C:11]2[C:19]3[C:14](=[N:15][C:16]([NH:20][CH2:21][CH2:22][N:23]4[CH2:28][CH2:27][O:26][CH2:25][CH2:24]4)=[N:17][CH:18]=3)[NH:13][N:12]=2)[CH:8]=[CH:7][N:6]=1)[C:38]1[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=1)([CH3:32])([CH3:30])[CH3:31]

Participants

3

Reactant 2

HCID 2771847tert-butyl N-(2-amino-2-phenylethyl)carbamateHCID 178504845HCID 178504845, compound

Product 1

HCID 178453677HCID 178453677, compound

Procedure

(2-{4-[6-(2-Morpholin-4-yl-ethylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-pyrimidin-2-ylamino}-2-phenyl-ethyl)-carbamic acid tert-butyl ester was prepared from [3-(2-methanesulfonyl-pyrimidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-(2-morpholin-4-yl-ethyl)-amine (from Example 11 supra) and (2-amino-2-phenyl-ethyl)-carbamic acid tert-butyl ester (from Example 1 supra) by following the method in Example 61.

Sources & evidence

ORD record
ord-359a19f6d6de4832b44fbfdb81ef6e58
Source dataset
uspto-grants-2013_01
Patent number
US08362023B2

Reaction notes

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