Hydrochloric Acid → N1-{4-[6-(2-morpholin-4-yl-ethylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-pyrimidin-2-yl}-1-phenyl-ethane-1,2-diamine

HRID 1809774ノート

反応式

HRID 1809774 の反応式
C(OC(=O)[NH:7][CH2:8][CH:9]([NH:16][C:17]1[N:22]=[C:21]([C:23]2[C:31]3[C:26](=[N:27][C:28]([NH:32][CH2:33][CH2:34][N:35]4[CH2:40][CH2:39][O:38][CH2:37][CH2:36]4)=[N:29][CH:30]=3)[NH:25][N:24]=2)[CH:20]=[CH:19][N:18]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(C)(C)C.Cl>CCO>[N:35]1([CH2:34][CH2:33][NH:32][C:28]2[N:27]=[C:26]3[NH:25][N:24]=[C:23]([C:21]4[CH:20]=[CH:19][N:18]=[C:17]([NH:16][CH:9]([C:10]5[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=5)[CH2:8][NH2:7])[N:22]=4)[C:31]3=[CH:30][N:29]=2)[CH2:40][CH2:39][O:38][CH2:37][CH2:36]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 178453677HCID 178453677、化合物

生成物 1

HCID 178511333N1-{4-[6-(2-morpholin-4-yl-ethylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-pyrimidin-2-yl}-1-phenyl-ethane-1,2-diamine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

(2-{4-[6-(2-Morpholin-4-yl-ethylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-pyrimidin-2-ylamino}-2-phenyl-ethyl)-carbamic acid tert-butyl ester (130 mg, 0.23 mmol) was dissolved in EtOH (4 mL), then HCl (4 mL) was added. The reaction mixture was stirred at room temperature for 15 hours. The solvent was removed under reduced pressure to afford the crude product which was purified by prep-HPLC to afford N1-{4-[6-(2-morpholin-4-yl-ethylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-pyrimidin-2-yl}-1-phenyl-ethane-1,2-diamine; hydrochloride. (Yield 25 mg, 19.1%).

後処理

  1. customThe solvent was removed under reduced pressure
  2. customto afford the crude product which
  3. customwas purified by prep-HPLC

出典と根拠

ORDレコード
ord-0d1a2d14bacb4bfcb48ed42c84f18be3
出典データセット
uspto-grants-2013_01
特許番号
US08362023B2

反応ノート

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