HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → (3R*,4R*)-4-(3-Bromo-phenyl)-3-hydroxy-piperidine-1-carboxylic acid t-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | tert-butyl 4-(3-bromophenyl)-3,6-dihydropyridine-1(2H)-carboxylate | HCID 66836951 | — |
| Product | (3R*,4R*)-4-(3-Bromo-phenyl)-3-hydroxy-piperidine-1-carboxylic acid t-butyl ester | HCID 67542384 | — |
Reaction Steps
The title compound is prepared analogously as described for the title B compound in Example 1 from the title A compound, 4-(3-bromo-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid t-butyl ester: MS 356.2/358.1 [M+H]+; retention time 6.59 min (HPLC, Nucleosil C18; 5→100% CH3CN in H2O within 8 min).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08362040B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-fbb98a918eff48f8a83bf622867ba45e |
| Source note | uspto-grants-2013_01 |