tert-butyl N-{[(2S)-piperidin-2-yl]methyl}carbamate → ((S)-1-{1-[4-(4-Fluoro-phenyl)-1-methyl-1H-pyrazol-3-yl]-methanoyl}-piperidin-2-ylmethyl)-carbamic acid tert butyl ester

HRID 18098Notes

Reaction equation

HRID 18098 reaction equation
[C:1]([O:5][C:6](=[O:15])[NH:7][CH2:8][C@@H:9]1[CH2:14][CH2:13][CH2:12][CH2:11][NH:10]1)([CH3:4])([CH3:3])[CH3:2].[F:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[C:24]([C:29](O)=[O:30])=[N:25][N:26]([CH3:28])[CH:27]=2)=[CH:19][CH:18]=1>>[C:1]([O:5][C:6](=[O:15])[NH:7][CH2:8][C@@H:9]1[CH2:14][CH2:13][CH2:12][CH2:11][N:10]1[C:29]([C:24]1[C:23]([C:20]2[CH:21]=[CH:22][C:17]([F:16])=[CH:18][CH:19]=2)=[CH:27][N:26]([CH3:28])[N:25]=1)=[O:30])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 1501973tert-butyl N-{[(2S)-piperidin-2-yl]methyl}carbamateHCID 197686484-(4-fluorophenyl)-1-methyl-1H-pyrazole-3-carboxylic acid

Product 1

HCID 86626014((S)-1-{1-[4-(4-Fluoro-phenyl)-1-methyl-1H-pyrazol-3-yl]-methanoyl}-piperidin-2-ylmethyl)-carbamic acid tert butyl esterYield 95.2%

Procedure

The title compound (3.96 g) was prepared from (S)-1-piperidin-2-ylmethyl-carbamic acid tert butyl ester (2.14 g) and 4-(4-fluoro-phenyl)-1-methyl-1H-pyrazol-3-yl carboxylic acid (2.20 g) according to the method of D40.

Sources & evidence

ORD record
ord-6acbc4125a084f73a4ef287f3c71ea7c
Source dataset
uspto-grants-2010_06
Patent number
US07741329B2

Reaction notes

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