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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1809850Generated: November 1, 2026

1,4-Dioxane hydrochloride → n-{2-[(9s)-1-Oxa-7-azaspiro[4.4]non-9-ylamino]-2-oxoethyl}-3-(trifluoromethyl)benzamide

https://huagongshe.com/reaction/1809850

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-Dioxane hydrochlorideHCID 20443148—
ReactantTert-butyl (9s)-9-[({[3-(trifluoromethyl)benzoyl]amino}acetyl)amino]-1-oxa-7-azaspiro[4.4]nonane-7-carboxylateHCID 59556109—
Productn-{2-[(9s)-1-Oxa-7-azaspiro[4.4]non-9-ylamino]-2-oxoethyl}-3-(trifluoromethyl)benzamideHCID 59556036—

Reaction Steps

The intermediate of step G (0.18 g) was mixed with 5 mL of 4 N HCl/dioxane. The solution was stirred for 2 h and concentrated under vacuum. MS (M+H)+372.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08362003B2
Source datasetuspto-grants-2013_01
ORD IDord-62d313f1b004478cab9018175eb46a67
Source noteuspto-grants-2013_01