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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1809876Generated: October 31, 2026

5-(8-Hydroxy-1,4-dioxaspiro[4.5]dec-8-yl)pyridine-2-carbonitrile → 5-(1-Hydroxy-4-oxocyclohexyl)pyridine-2-carbonitrile

https://huagongshe.com/reaction/1809876

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(8-Hydroxy-1,4-dioxaspiro[4.5]dec-8-yl)pyridine-2-carbonitrileHCID 66787096—
Reactant4-(1-Hydroxy-4-oxocyclohexyl)benzonitrileHCID 66787229—
Product5-(1-Hydroxy-4-oxocyclohexyl)pyridine-2-carbonitrileHCID 66787388—

Reaction Steps

The title compound was synthesized from 5-(8-hydroxy-1,4-dioxaspiro[4.5]dec-8-yl)pyridine-2-carbonitrile using the same typical deprotection procedure as for 4-(1-hydroxy-4-oxocyclohexyl)benzonitrile.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08362003B2
Source datasetuspto-grants-2013_01
ORD IDord-069b836fec4c48da81812be9972d6948
Source noteuspto-grants-2013_01