Sodium Hydroxide → HCID 178462469, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (Z)-methyl 4-(3-ethyl-4-phenylthiazol-2(3H)-ylideneamino)benzoate (2-4) (50 mg, 0.19 mmol) in MeOH (1 mL) is added a solution of NaOH (1.0 mL of 1N aqueous solution, 1.0 mmol) and MeOH (0.5 mL). The mixture is heated at 80° C. for 1 hour and the solvent is removed. The residue is purified by preparative LC/MS to provide (Z)-4-(3-ethyl-4-phenylthiazol-2(3H)-ylideneamino)benzoic acid (2-5). HPLC-MS calculated for C18H16N2O2S (M+H+) 325.1. found 325.1.

Provenance & Evidence