2-Amino-2-cyanoacetamide → HCID 178468825, compound

Participants

Reaction Steps

30.5 g (0.09 M) of ethyl 5-benzylsulfanylcarbonimidoylmethylfuran-2-carboxylate, 8.9 g (0.09 M) of aminocyanoacetamide and 7.5 g (0.09 M) of sodium hydrogen carbonate in 180 ml of methanol are refluxed with stirring for 5 hours. The crude product obtained is purified by chromatography on silica using a dichloromethane/methanol mixture (90/10) as eluent, to give 17 g of ethyl 5-(5-amino-4-carbamoyl-1H-imidazol-2-ylmethyl)furan-2-carboxylate in the form of a vitreous brown solid.

Provenance & Evidence