Sodium Hydroxide → HCID 178439174, compound

Participants

Reaction Conditions

Reaction Steps

1.8 g (4.24 mM) of ethyl 5-[4-carbamoyl-5-(4-propylbenzoylamino)-1H-imidazol-2-ylmethyl]furan-2-carboxylate are added to 10 ml of an ethanol/THF mixture (50-50). 4 ml of aqueous 3N sodium hydroxide solution are then added and the reaction medium is maintained at 40° C. with stirring for 2 hours. The reaction medium is allowed to cool and is acidified with acetic acid; a solid crystallizes. The solid is filtered off and washed with demineralized water to give, after drying, 1.7 g of 5-[4-carbamoyl-5-(4-propylbenzoylamino)-1H-imidazol-2-ylmethyl]furan-2-carboxylic acid.

Provenance & Evidence