1,1'-Thiocarbonyldiimidazole → HCID 59550995, compound

HRID 1809975Notes

Reaction equation

HRID 1809975 reaction equation
[CH:1]([N:4]1[C:12]2[C:7](=[C:8]([NH2:15])[CH:9]=[CH:10][C:11]=2[O:13][CH3:14])[CH:6]=[CH:5]1)([CH3:3])[CH3:2].[C:16](N1C=CN=C1)(N1C=CN=C1)=[S:17]>ClCCl>[CH:1]([N:4]1[C:12]2[C:7](=[C:8]([N:15]=[C:16]=[S:17])[CH:9]=[CH:10][C:11]=2[O:13][CH3:14])[CH:6]=[CH:5]1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 802641,1'-ThiocarbonyldiimidazoleHCID 59551030HCID 59551030, compound

Product 1

HCID 59550995HCID 59550995, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 1-isopropyl-7-methoxy-1H-indol-4-ylamine (U) (1 eq) in dichloromethane was added 1,1′-thiocarbonyldiimidazole (1.2 eq). The reaction was stirred for 2 hrs at room temperature then evaporated to dryness. Further purification by column chromatography produced the pure desired product.

Workup

  1. customthen evaporated to dryness
  2. customFurther purification by column chromatography

Sources & evidence

ORD record
ord-60bd575dd8214cbd8f89b24f92b99e3b
Source dataset
uspto-grants-2013_01
Patent number
US08362055B2

Reaction notes

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