4-Methoxyphenethyl alcohol → HCID 178490371, compound

HRID 1809989Notes

Reaction equation

HRID 1809989 reaction equation
CC([S:7][C:8]1[S:12][C:11]([NH:13][C:14]([N:16]([C@H:27]2[CH2:32][CH2:31][C@H:30]([CH3:33])[CH2:29][CH2:28]2)[CH2:17][CH2:18]CCC2C=CC=CC=2)=[O:15])=[N:10][CH:9]=1)(C)C(O)=O.[CH3:34][O:35][C:36]1[CH:41]=[CH:40][C:39](CCO)=[CH:38][CH:37]=1.C([O:47][C:48](=[O:60])[C:49]([CH3:59])([CH3:58])[CH2:50]SC1SC(N)=NC=1)C>>[CH3:34][O:35][C:36]1[CH:37]=[CH:38][C:39]([CH2:18][CH2:17][N:16]([C@H:27]2[CH2:28][CH2:29][C@H:30]([CH3:33])[CH2:31][CH2:32]2)[C:14](=[O:15])[NH:13][C:11]2[S:12][C:8]([S:7][CH2:50][C:49]([CH3:59])([CH3:58])[C:48]([OH:60])=[O:47])=[CH:9][N:10]=2)=[CH:40][CH:41]=1

Participants

4

Reactant 3

HCID 697054-Methoxyphenethyl alcoholHCID 574814293-(2-Amino-thiazol-5-ylsulfanyl)-2,2-dimethyl-propionic acid ethyl esterHCID 178460760HCID 178460760, compound

Product 1

HCID 178490371HCID 178490371, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of 2-methyl-2-{2-[3-(trans-4-methyl-cyclohexyl)-3-(4-phenyl-butyl)-ureido]-thiazol-5-ylsulfanyl}-propionic acid using 2-(4-methoxy-phenyl)-ethanol and 3-(2-amino-thiazol-5-ylsulfanyl)-2,2-dimethyl-propionic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-604c0fdeae3d4b8e9b95397a85f0b681
Source dataset
uspto-grants-2013_01
Patent number
US08362049B2

Reaction notes

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