Thiophenol → HCID 178454943, compound

HRID 1809995Notes

Reaction equation

HRID 1809995 reaction equation
CO[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9][CH2:10][CH2:11][CH2:12][N:13]([C@H:29]1[CH2:34][CH2:33][C@H:32]([CH3:35])[CH2:31][CH2:30]1)[C:14](=[O:28])[NH:15][C:16]1[S:17][C:18]([S:21]C(C)(C)C(O)=O)=[CH:19][N:20]=1.C1(S)C=CC=CC=1.C([O:45][C:46](=[O:58])[C:47]([CH3:57])([CH3:56])[CH2:48]SC1SC(N)=NC=1)C>>[CH3:48][C:47]([CH3:57])([CH2:56][S:21][C:18]1[S:17][C:16]([NH:15][C:14]([N:13]([C@H:29]2[CH2:30][CH2:31][C@H:32]([CH3:35])[CH2:33][CH2:34]2)[CH2:12][CH2:11][CH2:10][S:9][C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][CH:3]=2)=[O:28])=[N:20][CH:19]=1)[C:46]([OH:58])=[O:45]

Participants

4

Reactant 3

HCID 7969ThiophenolHCID 574814293-(2-Amino-thiazol-5-ylsulfanyl)-2,2-dimethyl-propionic acid ethyl esterHCID 178489631HCID 178489631, compound

Product 1

HCID 178454943HCID 178454943, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis 2-{2-[3-[3-(2-methoxy-phenylsulfanyl)-propyl]-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-2-methyl-propionic acid using thiophenol and 3-(2-amino-thiazol-5-ylsulfanyl)-2,2-dimethyl-propionic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-e15f12893cc8483ca03dfdda148f98f2
Source dataset
uspto-grants-2013_01
Patent number
US08362049B2

Reaction notes

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