Phenol → HCID 178454942, compound

HRID 1809997Notes

Reaction equation

HRID 1809997 reaction equation
CC([S:7][C:8]1[S:12][C:11]([NH:13][C:14]([N:16]([C@H:27]2[CH2:32][CH2:31][C@H:30]([CH3:33])[CH2:29][CH2:28]2)[CH2:17][CH2:18][CH2:19][O:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[O:15])=[N:10][CH:9]=1)(C)C(O)=O.C1(O)C=CC=CC=1.C([O:43][C:44](=[O:56])[C:45]([CH3:55])([CH3:54])[CH2:46]SC1SC(N)=NC=1)C>>[CH3:46][C:45]([CH3:55])([CH2:54][S:7][C:8]1[S:12][C:11]([NH:13][C:14]([N:16]([C@H:27]2[CH2:32][CH2:31][C@H:30]([CH3:33])[CH2:29][CH2:28]2)[CH2:17][CH2:18][CH2:19][O:20][C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)=[O:15])=[N:10][CH:9]=1)[C:44]([OH:56])=[O:43]

Participants

4

Reactant 3

HCID 996PhenolHCID 574814293-(2-Amino-thiazol-5-ylsulfanyl)-2,2-dimethyl-propionic acid ethyl esterHCID 178460761HCID 178460761, compound

Product 1

HCID 178454942HCID 178454942, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis 2-methyl-2-{2-[3-(trans-4-methyl-cyclohexyl)-3-(3-phenoxy-propyl)-ureido]-thiazol-5-ylsulfanyl}-propionic acid using phenol and 3-(2-amino-thiazol-5-ylsulfanyl)-2,2-dimethyl-propionic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-117e170f155b41d9adb40b8613ad8e60
Source dataset
uspto-grants-2013_01
Patent number
US08362049B2

Reaction notes

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