Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 18100Generated: October 25, 2026

2-Chloro-4-cyanopyridine → (S)-2-[(4-Cyano-pyridin-2-ylamino)-methyl]-piperidine-1-carboxylic acid tert butyl ester

https://huagongshe.com/reaction/18100

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-4-cyanopyridineHCID 568638—
Reactanttert-Butyl (2S)-2-(aminomethyl)piperidine-1-carboxylateHCID 1502020—
Product(S)-2-[(4-Cyano-pyridin-2-ylamino)-methyl]-piperidine-1-carboxylic acid tert butyl esterHCID 8659367914.3%

Reaction Steps

The title compound (0.24 g) was prepared from (S)-2-aminomethyl-piperidine-1-carboxylic acid tert-butyl ester (1.14 g) and 2-chloro-4-cyanopyridine (0.74 g) according to the method of D28.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07741329B2
Source datasetuspto-grants-2010_06
ORD IDord-a4aa2bcb7c574cd0b7948557a8d0a9d0
Source noteuspto-grants-2010_06