Thiophenol → HCID 178461332, compound

HRID 1810002Notes

Reaction equation

HRID 1810002 reaction equation
CO[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9][CH2:10][CH2:11][CH2:12][N:13]([C@H:29]1[CH2:34][CH2:33][C@H:32]([CH3:35])[CH2:31][CH2:30]1)[C:14](=[O:28])[NH:15][C:16]1[S:17][C:18]([S:21][C:22](C)([CH3:26])C(O)=O)=[CH:19][N:20]=1.C1(S)C=CC=CC=1.C([O:45][C:46](=[O:56])CCSC1SC(N)=NC=1)C>>[CH3:35][C@H:32]1[CH2:31][CH2:30][C@H:29]([N:13]([CH2:12][CH2:11][CH2:10][S:9][C:4]2[CH:3]=[CH:8][CH:7]=[CH:6][CH:5]=2)[C:14](=[O:28])[NH:15][C:16]2[S:17][C:18]([S:21][CH2:22][CH2:26][C:46]([OH:56])=[O:45])=[CH:19][N:20]=2)[CH2:34][CH2:33]1

Participants

4

Reactant 3

HCID 7969ThiophenolHCID 57481428Ethyl 3-[(2-amino-1,3-thiazol-5-YL)sulfanyl]propanoateHCID 178489631HCID 178489631, compound

Product 1

HCID 178461332HCID 178461332, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis 2-{2-[3-[3-(2-methoxy-phenylsulfanyl)-propyl]-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-2-methyl-propionic acid using thiophenol and 3-(2-amino-thiazol-5-ylsulfanyl)-propionic acid ethyl ester

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-7046b909e81e4189b5210e0bf7641e5c
Source dataset
uspto-grants-2013_01
Patent number
US08362049B2

Reaction notes

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