1-(Bromomethyl)-2-chloro-4-fluorobenzene → HCID 178454948, compound

HRID 1810008Notes

Reaction equation

HRID 1810008 reaction equation
[Cl:1][C:2]1[CH:35]=[CH:34][CH:33]=[CH:32][C:3]=1[CH2:4][O:5][CH2:6][CH2:7][N:8]([C@H:25]1[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]1)[C:9](=[O:24])[NH:10][C:11]1[S:12][C:13]([S:16][CH2:17][C:18]([CH3:23])([CH3:22])[C:19]([OH:21])=[O:20])=[CH:14][N:15]=1.BrCC1C=CC([F:44])=CC=1Cl.C(OC(=O)C(C)(C)CSC1SC(N)=NC=1)C>>[Cl:1][C:2]1[CH:35]=[C:34]([F:44])[CH:33]=[CH:32][C:3]=1[CH2:4][O:5][CH2:6][CH2:7][N:8]([C@H:25]1[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]1)[C:9](=[O:24])[NH:10][C:11]1[S:12][C:13]([S:16][CH2:17][C:18]([CH3:22])([CH3:23])[C:19]([OH:21])=[O:20])=[CH:14][N:15]=1

Participants

4

Reactant 3

HCID 27250621-(Bromomethyl)-2-chloro-4-fluorobenzeneHCID 574814293-(2-Amino-thiazol-5-ylsulfanyl)-2,2-dimethyl-propionic acid ethyl esterHCID 178454946HCID 178454946, compound

Product 1

HCID 178454948HCID 178454948, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of 3-{2-[3-[2-(2-chloro-benzyloxy)-ethyl]-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid using 1-bromomethyl-2-chloro-4-fluoro-benzene and 3-(2-amino-thiazol-5-ylsulfanyl)-2,2-dimethyl-propionic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-0c85c2aa43d14a12b1ef2d7c49405738
Source dataset
uspto-grants-2013_01
Patent number
US08362049B2

Reaction notes

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