4-Methoxybenzenethiol → HCID 178492794, compound

HRID 1810021Notes

Reaction equation

HRID 1810021 reaction equation
CO[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9][CH2:10][CH2:11][CH2:12][N:13]([C@H:29]1[CH2:34][CH2:33][C@H:32]([CH3:35])[CH2:31][CH2:30]1)[C:14](=[O:28])[NH:15][C:16]1[S:17][C:18]([S:21][C:22]([CH3:27])([CH3:26])[C:23]([OH:25])=[O:24])=[CH:19][N:20]=1.[CH2:36]([O:38]C(=O)C(SC1SC(N)=NC=1)(C)C)C.COC1C=CC(S)=CC=1>>[CH3:36][O:38][C:7]1[CH:6]=[CH:5][C:4]([S:9][CH2:10][CH2:11][CH2:12][N:13]([C@H:29]2[CH2:30][CH2:31][C@H:32]([CH3:35])[CH2:33][CH2:34]2)[C:14](=[O:28])[NH:15][C:16]2[S:17][C:18]([S:21][C:22]([CH3:26])([CH3:27])[C:23]([OH:25])=[O:24])=[CH:19][N:20]=2)=[CH:3][CH:8]=1

Participants

4

Reactant 3

HCID 127654-MethoxybenzenethiolHCID 57481427Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoateHCID 178489631HCID 178489631, compound

Product 1

HCID 178492794HCID 178492794, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis 2-{2-[3-[3-(2-methoxy-phenylsulfanyl)-propyl]-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-2-methyl-propionic acid using 2-(2-amino-thiazol-5-ylsulfanyl)-2-methyl-propionic acid ethyl ester and 4-methoxy-thiophenol.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-5e2517b9365d4125a0e25226dabf53b4
Source dataset
uspto-grants-2013_01
Patent number
US08362049B2

Reaction notes

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