HRID1810025

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2760732

2-(Trifluoromethoxy)thiophenol

C7H5F3OS

HCID57481427

Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoate

C9H14N2O2S2

结构：COc1ccccc1SCCCN(C(=O)Nc1ncc(SC(C)(C)C(=O)O)s1)[C@H]1CC[C@H](C)CC1

HCID178489631

未命名化合物

PRODUCTS

生成物

结构：CC(C)(Sc1cnc(NC(=O)N(CCCSc2ccccc2OC(F)(F)F)[C@H]2CC[C@H](C)CC2)s1)C(=O)O

HCID178460765

未命名化合物

PROCEDURE

实验过程

The compound was prepared following an analogous procedure to the one described for the synthesis 2-{2-[3-[3-(2-methoxy-phenylsulfanyl)-propyl]-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-2-methyl-propionic acid using 2-trifluoromethoxy-thiophenol and 2-(2-amino-thiazol-5-ylsulfanyl)-2-methyl-propionic acid ethyl ester.

WORKUP

后处理

customThe compound was prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-93e86e0a15f140a99c2adbd02a4e9676
来源数据集: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08362049B2
来源说明: uspto-grants-2013_01

反应 SMILES

COC1C=CC=CC=1S[CH2:10][CH2:11][CH2:12][N:13]([C@H:29]1[CH2:34][CH2:33][C@H:32]([CH3:35])[CH2:31][CH2:30]1)[C:14](=[O:28])[NH:15][C:16]1[S:17][C:18]([S:21][C:22]([CH3:27])([CH3:26])[C:23]([OH:25])=[O:24])=[CH:19][N:20]=1.[F:36][C:37]([F:47])([F:46])[O:38][C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=1[SH:45].C(OC(=O)C(SC1SC(N)=NC=1)(C)C)C>>[CH3:26][C:22]([S:21][C:18]1[S:17][C:16]([NH:15][C:14]([N:13]([C@H:29]2[CH2:34][CH2:33][C@H:32]([CH3:35])[CH2:31][CH2:30]2)[CH2:12][CH2:11][CH2:10][S:45][C:40]2[CH:41]=[CH:42][CH:43]=[CH:44][C:39]=2[O:38][C:37]([F:36])([F:46])[F:47])=[O:28])=[N:20][CH:19]=1)([CH3:27])[C:23]([OH:25])=[O:24]