Sulfone, 2-chloroethyl p-tolyl → HCID 178427305, compound

HRID 1810031Notes

Reaction equation

HRID 1810031 reaction equation
C[C:2]([S:7][C:8]1[S:12][C:11]([NH:13][C:14]([N:16]([C@H:25]2[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]2)[CH2:17][CH2:18]C2C=CC=CC=2)=[O:15])=[N:10][CH:9]=1)(C)[C:3]([OH:5])=[O:4].ClCC[S:35]([C:38]1[CH:43]=[CH:42][C:41]([CH3:44])=[CH:40][CH:39]=1)(=[O:37])=[O:36].C(OC(=O)CSC1SC(N)=NC=1)C>>[CH3:31][C@H:28]1[CH2:29][CH2:30][C@H:25]([N:16]([CH2:17][CH2:18][S:35]([C:38]2[CH:43]=[CH:42][C:41]([CH3:44])=[CH:40][CH:39]=2)(=[O:37])=[O:36])[C:14](=[O:15])[NH:13][C:11]2[S:12][C:8]([S:7][CH2:2][C:3]([OH:5])=[O:4])=[CH:9][N:10]=2)[CH2:26][CH2:27]1

Participants

4

Reactant 3

HCID 188162Sulfone, 2-chloroethyl p-tolylHCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 178460750HCID 178460750, compound

Product 1

HCID 178427305HCID 178427305, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of 2-methyl-2-{2-[3-(trans-4-methyl-cyclohexyl)-3-phenethyl-ureido]-thiazol-5-ylsulfanyl}-propionic acid using 1-(2-chloro-ethanesulfonyl)-4-methyl-benzene and (2-aminothiazol-5-ylsulfanyl)acetic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-2900289d51f14631a4bbe104fed4e5f9
Source dataset
uspto-grants-2013_01
Patent number
US08362049B2

Reaction notes

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