Ethyl 2-(2-aminothiazol-5-ylthio)acetate → HCID 178461320, compound

HRID 1810040Notes

Reaction equation

HRID 1810040 reaction equation
ClC1C=C(CC[CH2:10][N:11]([C@H:25]2[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]2)[C:12](=[O:24])[NH:13][C:14]2[S:15][C:16]([S:19][CH2:20][C:21]([OH:23])=[O:22])=[CH:17][N:18]=2)C=CC=1.[Cl:32][C:33]1[CH:34]=[CH:35][C:36]2[O:40][CH:39]=[C:38]([CH2:41][CH2:42]C(O)=O)[C:37]=2[CH:46]=1.C(OC(=O)CSC1SC(N)=NC=1)C>>[Cl:32][C:33]1[CH:34]=[CH:35][C:36]2[O:40][CH:39]=[C:38]([CH2:41][CH2:42][CH2:10][N:11]([C@H:25]3[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]3)[C:12](=[O:24])[NH:13][C:14]3[S:15][C:16]([S:19][CH2:20][C:21]([OH:23])=[O:22])=[CH:17][N:18]=3)[C:37]=2[CH:46]=1

Participants

4

Reactant 3

HCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 574314823-(5-Chloro-benzofuran-3-yl)-propionic acidHCID 178461316HCID 178461316, compound

Product 1

HCID 178461320HCID 178461320, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of {2-[-3-[3-(3-chloro-phenyl)-propyl]-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid using 3-(5-chloro-benzofuran-3-yl)-propionic acid and (2-aminothiazol-5-ylsulfanyl)acetic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-94a77205cca848869b2bfff39bfa818d
Source dataset
uspto-grants-2013_01
Patent number
US08362049B2

Reaction notes

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