trans-2-Phenylcyclopropanecarboxylic acid → HCID 178461335, compound

HRID 1810042Notes

Reaction equation

HRID 1810042 reaction equation
Cl[C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][CH2:10][N:11]([C@H:25]2[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]2)[C:12](=[O:24])[NH:13][C:14]2[S:15][C:16]([S:19][CH2:20][C:21]([OH:23])=[O:22])=[CH:17][N:18]=2)[CH:5]=[CH:6][CH:7]=1.[C:32]1([C@@H]2C[C@H]2C(O)=O)C=CC=CC=1.C(OC(=O)CSC1SC(N)=NC=1)C>>[CH3:31][C@H:28]1[CH2:29][CH2:30][C@H:25]([N:11]([CH2:10][C@@H:9]2[CH2:32][C@H:8]2[C:4]2[CH:5]=[CH:6][CH:7]=[CH:2][CH:3]=2)[C:12](=[O:24])[NH:13][C:14]2[S:15][C:16]([S:19][CH2:20][C:21]([OH:23])=[O:22])=[CH:17][N:18]=2)[CH2:26][CH2:27]1

Participants

4

Reactant 3

HCID 237413trans-2-Phenylcyclopropanecarboxylic acidHCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 178461316HCID 178461316, compound

Product 1

HCID 178461335HCID 178461335, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of {2-[-3-[3-(3-chloro-phenyl)-propyl]-3-(trans-4-methyl-cyclohexy)-ureido]-thiazol-5-ylsulfanyl}-acetic acid using trans-2-phenylcyclopropanecarboxylic acid and (2-aminothiazol-5-ylsulfanyl)acetic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-f28caca5ee2845f29a79d681128c5708
Source dataset
uspto-grants-2013_01
Patent number
US08362049B2

Reaction notes

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