1-Chloro-2-methanesulfonylethane → HCID 178504892, compound

HRID 1810043Notes

Reaction equation

HRID 1810043 reaction equation
C[C:2]([S:7][C:8]1[S:12][C:11]([NH:13][C:14]([N:16]([C@H:25]2[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]2)[CH2:17][CH2:18]C2C=CC=CC=2)=[O:15])=[N:10][CH:9]=1)(C)[C:3]([OH:5])=[O:4].ClC[CH2:34][S:35](C)(=[O:37])=[O:36].C(OC(=O)CSC1SC(N)=NC=1)C>>[CH3:34][S:35]([CH2:18][CH2:17][N:16]([C@H:25]1[CH2:26][CH2:27][C@H:28]([CH3:31])[CH2:29][CH2:30]1)[C:14](=[O:15])[NH:13][C:11]1[S:12][C:8]([S:7][CH2:2][C:3]([OH:5])=[O:4])=[CH:9][N:10]=1)(=[O:37])=[O:36]

Participants

4

Reactant 3

HCID 3035331-Chloro-2-methanesulfonylethaneHCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 178460750HCID 178460750, compound

Product 1

HCID 178504892HCID 178504892, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of 2-methyl-2-{2-[3-(trans-4-methyl-cyclohexyl)-3-phenethyl-ureido]-thiazol-5-ylsulfanyl}-propionic acid using 1-chloro-2-methanesulfonyl-ethane (Prepared as described in Chem. Ber. 1894, 27, 3048) and (2-aminothiazol-5-ylsulfanyl)acetic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-b71ba2772ac543e6b5b61194f21a9cc3
Source dataset
uspto-grants-2013_01
Patent number
US08362049B2

Reaction notes

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