Indole-3-Butyric Acid → HCID 178461327, compound

HRID 1810044Notes

Reaction equation

HRID 1810044 reaction equation
Cl[C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][CH2:10][N:11]([C@H:25]2[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]2)[C:12](=[O:24])[NH:13][C:14]2[S:15][C:16]([S:19][CH2:20][C:21]([OH:23])=[O:22])=[CH:17][N:18]=2)[CH:5]=[CH:6][CH:7]=1.[NH:32]1[C:40]2C(=CC=CC=2)[C:34](CCCC(O)=O)=[CH:33]1.C(OC(=O)CSC1SC(N)=NC=1)C>>[NH:32]1[C:33]2[C:2](=[CH:7][CH:6]=[CH:5][CH:34]=2)[C:3]([CH2:4][CH2:8][CH2:9][CH2:10][N:11]([C@H:25]2[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]2)[C:12](=[O:24])[NH:13][C:14]2[S:15][C:16]([S:19][CH2:20][C:21]([OH:23])=[O:22])=[CH:17][N:18]=2)=[CH:40]1

Participants

4

Reactant 3

HCID 8617Indole-3-Butyric AcidHCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 178461316HCID 178461316, compound

Product 1

HCID 178461327HCID 178461327, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of {2-[-3-[3-(3-chloro-phenyl)-propyl]-3-(trans-4-methyl-cyclohexy)-ureido]-thiazol-5-ylsulfanyl}-acetic acid using 4-(1H-indol-3-yl)-butyric acid and (2-aminothiazol-5-ylsulfanyl)acetic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-8a6356600eca4a52b45c5b49f47cc9ea
Source dataset
uspto-grants-2013_01
Patent number
US08362049B2

Reaction notes

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