1,2,3,4-Tetrahydro-2-naphthoic acid → HCID 178461308, compound

HRID 1810048Notes

Reaction equation

HRID 1810048 reaction equation
Cl[C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][CH2:10][N:11]([C@H:25]2[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]2)[C:12](=[O:24])[NH:13][C:14]2[S:15][C:16]([S:19][CH2:20][C:21]([OH:23])=[O:22])=[CH:17][N:18]=2)[CH:5]=[CH:6][CH:7]=1.[CH2:32]1C2C(=CC=CC=2)CC[CH:33]1C(O)=O.C(OC(=O)CSC1SC(N)=NC=1)C>>[CH3:31][C@H:28]1[CH2:27][CH2:26][C@H:25]([N:11]([CH2:10][CH:9]2[CH2:33][CH2:32][C:3]3[C:4](=[CH:5][CH:6]=[CH:7][CH:2]=3)[CH2:8]2)[C:12](=[O:24])[NH:13][C:14]2[S:15][C:16]([S:19][CH2:20][C:21]([OH:23])=[O:22])=[CH:17][N:18]=2)[CH2:30][CH2:29]1

Participants

4

Reactant 3

HCID 1013701,2,3,4-Tetrahydro-2-naphthoic acidHCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 178461316HCID 178461316, compound

Product 1

HCID 178461308HCID 178461308, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of {2-[-3-[3-(3-chloro-phenyl)-propyl]-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid using 1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid and (2-aminothiazol-5-ylsulfanyl)acetic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-0d12bb0aa69d4b95a7ae660f9538514a
Source dataset
uspto-grants-2013_01
Patent number
US08362049B2

Reaction notes

Loading…