3,4-Dimethoxyphenethyl bromide → HCID 178490374, compound

HRID 1810065Notes

Reaction equation

HRID 1810065 reaction equation
[CH3:1][C:2]([S:7][C:8]1[S:12][C:11]([NH:13][C:14]([N:16]([C@H:25]2[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]2)CCC2C=CC=CC=2)=[O:15])=[N:10][CH:9]=1)([CH3:6])[C:3]([OH:5])=[O:4].Br[CH2:33][CH2:34][C:35]1[CH:40]=[CH:39][C:38]([O:41][CH3:42])=[C:37]([O:43][CH3:44])[CH:36]=1.C(OC(=O)C(SC1SC(N)=NC=1)(C)C)C>>[CH3:44][O:43][C:37]1[CH:36]=[C:35]([CH2:34][CH2:33][N:16]([C@H:25]2[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]2)[C:14](=[O:15])[NH:13][C:11]2[S:12][C:8]([S:7][C:2]([CH3:6])([CH3:1])[C:3]([OH:5])=[O:4])=[CH:9][N:10]=2)[CH:40]=[CH:39][C:38]=1[O:41][CH3:42]

Participants

4

Reactant 3

HCID 114706023,4-Dimethoxyphenethyl bromideHCID 57481427Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoateHCID 178460750HCID 178460750, compound

Product 1

HCID 178490374HCID 178490374, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of 2-methyl-2-{2-[3-(trans-4-methyl-cyclohexyl)-3-phenethyl-ureido]-thiazol-5-ylsulfanyl}-propionic acid using 1-(2-bromo-ethyl)-3,4-dimethoxy-benzene and 2-(2-amino-thiazol-5-ylsulfanyl)-2-methyl-propionic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-e0c865e2830c4e87a6d2bd30bb247f74
Source dataset
uspto-grants-2013_01
Patent number
US08362049B2

Reaction notes

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