HRID1810072

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID57481427

Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoate

C9H14N2O2S2

HCID57481433

未命名化合物

结构：CC(C)(CSc1cnc(NC(=O)N(CCOCc2ccccc2Cl)[C@H]2CC[C@H](C)CC2)s1)C(=O)O

HCID178454946

未命名化合物

PRODUCTS

生成物

结构：C[C@H]1CC[C@H](N(CCOCc2ccccc2Cl)C(=O)Nc2ncc(SC3(C(=O)O)CCC3)s2)CC1

HCID178461338

未命名化合物

PROCEDURE

实验过程

The compound was prepared following an analogous procedure to the one described for the synthesis of 3-{2-[3-[2-(2-chloro-benzyloxy)-ethyl]-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid using 1-(2-amino-thiazol-5-ylsulfanyl)-cyclobutanecarboxylic acid prepared using the procedure for the preparation of 2-(2-amino-thiazol-5-ylsulfanyl)-2-methyl-propionic acid ethyl ester.

WORKUP

后处理

customThe compound was prepared
customprepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5458232c80b747b98b0e81a167305abe
来源数据集: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08362049B2
来源说明: uspto-grants-2013_01

反应 SMILES

[Cl:1][C:2]1[CH:35]=[CH:34][CH:33]=[CH:32][C:3]=1[CH2:4][O:5][CH2:6][CH2:7][N:8]([C@H:25]1[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]1)[C:9](=[O:24])NC1SC(SCC(C)(C)C(O)=O)=CN=1.[NH2:36][C:37]1[S:38][C:39]([S:42][C:43]2([C:47]([OH:49])=[O:48])[CH2:46][CH2:45][CH2:44]2)=[CH:40][N:41]=1.C(OC(=O)C(SC1SC(N)=NC=1)(C)C)C>>[Cl:1][C:2]1[CH:35]=[CH:34][CH:33]=[CH:32][C:3]=1[CH2:4][O:5][CH2:6][CH2:7][N:8]([C@H:25]1[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]1)[C:9](=[O:24])[NH:36][C:37]1[S:38][C:39]([S:42][C:43]2([C:47]([OH:49])=[O:48])[CH2:44][CH2:45][CH2:46]2)=[CH:40][N:41]=1