Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoate → HCID 178461338, compound

HRID 1810072Notes

Reaction equation

HRID 1810072 reaction equation
[Cl:1][C:2]1[CH:35]=[CH:34][CH:33]=[CH:32][C:3]=1[CH2:4][O:5][CH2:6][CH2:7][N:8]([C@H:25]1[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]1)[C:9](=[O:24])NC1SC(SCC(C)(C)C(O)=O)=CN=1.[NH2:36][C:37]1[S:38][C:39]([S:42][C:43]2([C:47]([OH:49])=[O:48])[CH2:46][CH2:45][CH2:44]2)=[CH:40][N:41]=1.C(OC(=O)C(SC1SC(N)=NC=1)(C)C)C>>[Cl:1][C:2]1[CH:35]=[CH:34][CH:33]=[CH:32][C:3]=1[CH2:4][O:5][CH2:6][CH2:7][N:8]([C@H:25]1[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]1)[C:9](=[O:24])[NH:36][C:37]1[S:38][C:39]([S:42][C:43]2([C:47]([OH:49])=[O:48])[CH2:44][CH2:45][CH2:46]2)=[CH:40][N:41]=1

Participants

4

Reactant 3

HCID 57481427Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoateHCID 574814331-(2-Amino-thiazol-5-ylsulfanyl)-cyclobutanecarboxylic acidHCID 178454946HCID 178454946, compound

Product 1

HCID 178461338HCID 178461338, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of 3-{2-[3-[2-(2-chloro-benzyloxy)-ethyl]-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid using 1-(2-amino-thiazol-5-ylsulfanyl)-cyclobutanecarboxylic acid prepared using the procedure for the preparation of 2-(2-amino-thiazol-5-ylsulfanyl)-2-methyl-propionic acid ethyl ester.

Workup

  1. customThe compound was prepared
  2. customprepared

Sources & evidence

ORD record
ord-5458232c80b747b98b0e81a167305abe
Source dataset
uspto-grants-2013_01
Patent number
US08362049B2

Reaction notes

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