4-Methoxyphenethyl alcohol → HCID 178490370, compound

HRID 1810075Notes

Reaction equation

HRID 1810075 reaction equation
[CH3:1][C:2]([S:7][C:8]1[S:12][C:11]([NH:13][C:14]([N:16]([C@H:27]2[CH2:32][CH2:31][C@H:30]([CH3:33])[CH2:29][CH2:28]2)[CH2:17][CH2:18][CH2:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=CC=2)=[O:15])=[N:10][CH:9]=1)([CH3:6])[C:3]([OH:5])=[O:4].CO[C:36]1[CH:41]=CC(CCO)=C[CH:37]=1.[CH3:45][O:46]C(C1(SC2SC(N)=NC=2)CCCCC1)=O.C(OC(=O)C(SC1SC(N)=NC=1)(C)C)C>>[CH3:45][O:46][C:26]1[CH:25]=[CH:24][C:19]([CH2:18][CH2:17][N:16]([C@H:27]2[CH2:28][CH2:29][C@H:30]([CH3:33])[CH2:31][CH2:32]2)[C:14](=[O:15])[NH:13][C:11]2[S:12][C:8]([S:7][C:2]3([C:3]([OH:5])=[O:4])[CH2:6][CH2:41][CH2:36][CH2:37][CH2:1]3)=[CH:9][N:10]=2)=[CH:20][CH:21]=1

Participants

5

Reactant 4

HCID 697054-Methoxyphenethyl alcoholHCID 57481427Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoateHCID 57481435HCID 57481435, compoundHCID 178460760HCID 178460760, compound

Product 1

HCID 178490370HCID 178490370, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of 2-methyl-2-{2-[3-(trans-4-methyl-cyclohexyl)-3-(4-phenyl-butyl)-ureido]-thiazol-5-ylsulfanyl}-propionic acid using 2-(4-methoxyphenyl)-ethanol and 1-(2-amino-thiazol-5-ylsulfanyl)-cyclohexanecarboxylic acid methyl ester prepared using the procedure for the preparation of 2-(2-amino-thiazol-5-ylsulfanyl)-2-methyl-propionic acid ethyl ester.

Workup

  1. customThe compound was prepared
  2. customprepared

Sources & evidence

ORD record
ord-65484cc971254392a0b12310f04cb044
Source dataset
uspto-grants-2013_01
Patent number
US08362049B2

Reaction notes

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