3,4-Methylenedioxyphenethyl bromide → HCID 178460749, compound

HRID 1810079Notes

Reaction equation

HRID 1810079 reaction equation
[CH3:1][C:2]([S:7][C:8]1[S:12][C:11]([NH:13][C:14]([N:16]([C@H:25]2[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]2)[CH2:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[O:15])=[N:10][CH:9]=1)([CH3:6])[C:3]([OH:5])=[O:4].BrCCC1C=CC2[O:39][CH2:40][O:41]C=2C=1.C(OC(=O)C(SC1SC(N)=NC=1)(C)C)C>>[O:39]1[C:22]2[CH:21]=[CH:20][C:19]([CH2:18][CH2:17][N:16]([C@H:25]3[CH2:26][CH2:27][C@H:28]([CH3:31])[CH2:29][CH2:30]3)[C:14](=[O:15])[NH:13][C:11]3[S:12][C:8]([S:7][C:2]([CH3:1])([CH3:6])[C:3]([OH:5])=[O:4])=[CH:9][N:10]=3)=[CH:24][C:23]=2[O:41][CH2:40]1

Participants

4

Reactant 3

HCID 122072243,4-Methylenedioxyphenethyl bromideHCID 57481427Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoateHCID 178460750HCID 178460750, compound

Product 1

HCID 178460749HCID 178460749, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of 2-methyl-2-{2-[3-(trans-4-methyl-cyclohexyl)-3-phenethyl-ureido]-thiazol-5-ylsulfanyl}-propionic acid using 5-(2-bromo-ethyl)benzo[1,3]dioxole and 2-(2-amino-thiazol-5-ylsulfanyl)-2-methyl-propionic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-04c0e6a9fc0647ebbd452493761bcb29
Source dataset
uspto-grants-2013_01
Patent number
US08362049B2

Reaction notes

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