3-(Bromomethyl)pyridine hydrobromide → HCID 178461341, compound

HRID 1810080Notes

Reaction equation

HRID 1810080 reaction equation
Cl[C:2]1[CH:35]=[CH:34]C=[CH:32][C:3]=1[CH2:4][O:5][CH2:6][CH2:7][N:8]([C@H:25]1[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]1)[C:9](=[O:24])[NH:10][C:11]1[S:12][C:13]([S:16][CH2:17]C(C)(C)C(O)=O)=[CH:14][N:15]=1.Br.BrCC1C=[N:41]C=CC=1.C([O:47][C:48](=[O:57])CSC1SC(N)=NC=1)C>>[CH3:31][C@H:28]1[CH2:29][CH2:30][C@H:25]([N:8]([CH2:7][CH2:6][O:5][CH2:4][C:3]2[CH:32]=[N:41][CH:34]=[CH:35][CH:2]=2)[C:9](=[O:24])[NH:10][C:11]2[S:12][C:13]([S:16][CH2:17][C:48]([OH:57])=[O:47])=[CH:14][N:15]=2)[CH2:26][CH2:27]1

Participants

4

Reactant 3

HCID 127070373-(Bromomethyl)pyridine hydrobromideHCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 178454946HCID 178454946, compound

Product 1

HCID 178461341HCID 178461341, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of 3-{2-[3-[2-(2-chloro-benzyloxy)-ethyl]-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid using 3-bromomethylpyridine hydrobromide and (2-aminothiazol-5-ylsulfanyl)acetic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-84f4b877f67a4d72b946639cd9c2bfa2
Source dataset
uspto-grants-2013_01
Patent number
US08362049B2

Reaction notes

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