3-(Bromomethyl)-5-chloro-1-benzothiophene → HCID 178461343, compound

HRID 1810084Notes

Reaction equation

HRID 1810084 reaction equation
ClC1C=CC=CC=1C[O:5][CH2:6][CH2:7][N:8]([C@H:25]1[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]1)[C:9](=[O:24])[NH:10][C:11]1[S:12][C:13]([S:16][CH2:17]C(C)(C)C(O)=O)=[CH:14][N:15]=1.Br[CH2:37][C:38]1[C:39]2[CH:46]=[C:45]([Cl:47])[CH:44]=[CH:43][C:40]=2[S:41][CH:42]=1.C([O:50][C:51](=[O:60])CSC1SC(N)=NC=1)C>>[Cl:47][C:45]1[CH:44]=[CH:43][C:40]2[S:41][CH:42]=[C:38]([CH2:37][O:5][CH2:6][CH2:7][N:8]([C@H:25]3[CH2:26][CH2:27][C@H:28]([CH3:31])[CH2:29][CH2:30]3)[C:9](=[O:24])[NH:10][C:11]3[S:12][C:13]([S:16][CH2:17][C:51]([OH:60])=[O:50])=[CH:14][N:15]=3)[C:39]=2[CH:46]=1

Participants

4

Reactant 3

HCID 27798573-(Bromomethyl)-5-chloro-1-benzothiopheneHCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 178454946HCID 178454946, compound

Product 1

HCID 178461343HCID 178461343, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of 3-{2-[3-[2-(2-chloro-benzyloxy)-ethyl]-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid using 3-bromomethyl-5-chloro-benzo[b]thiophene and (2-aminothiazol-5-ylsulfanyl)acetic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-984f3be272014d83a829fe6ec148c536
Source dataset
uspto-grants-2013_01
Patent number
US08362049B2

Reaction notes

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