3-(m-Methoxyphenyl)propionic acid → HCID 178490103, compound

HRID 1810086Notes

Reaction equation

HRID 1810086 reaction equation
ClC1C=C(CCC[N:11]([C@H:25]2[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]2)[C:12](=[O:24])NC2SC(SCC(O)=O)=CN=2)C=CC=1.[CH3:32][O:33][C:34]1[CH:35]=[C:36]([CH2:40][CH2:41][C:42](O)=O)[CH:37]=[CH:38][CH:39]=1.C([O:47][C:48](=[O:59])[C:49]([S:52][C:53]1[S:57][C:56]([NH2:58])=[N:55][CH:54]=1)([CH3:51])[CH3:50])C>>[CH3:32][O:33][C:34]1[CH:35]=[C:36]([CH2:40][CH2:41][CH2:42][N:11]([C@H:25]2[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]2)[C:12](=[O:24])[NH:58][C:56]2[S:57][C:53]([S:52][C:49]([CH3:50])([CH3:51])[C:48]([OH:47])=[O:59])=[CH:54][N:55]=2)[CH:37]=[CH:38][CH:39]=1

Participants

4

Reactant 3

HCID 663363-(m-Methoxyphenyl)propionic acidHCID 57481427Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoateHCID 178461316HCID 178461316, compound

Product 1

HCID 178490103HCID 178490103, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of {2-[-3-[3-(3-chloro-phenyl)-propyl]-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid using 3-(3-methoxy-phenyl)-propionic acid and 2-(2-amino-thiazol-5-ylsulfanyl)-2-methyl-propionic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-e183442b00e34cefb8b1a9b14a948330
Source dataset
uspto-grants-2013_01
Patent number
US08362049B2

Reaction notes

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