4-p-Tolylbutyric acid → HCID 178424961, compound

HRID 1810089Notes

Reaction equation

HRID 1810089 reaction equation
ClC1C=C(CCC[N:11]([C@H:25]2[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]2)[C:12](=[O:24])NC2SC(SCC(O)=O)=CN=2)C=CC=1.[CH3:32][C:33]1[CH:38]=[CH:37][C:36]([CH2:39][CH2:40][CH2:41][C:42](O)=O)=[CH:35][CH:34]=1.C([O:47][C:48](=[O:59])[C:49]([S:52][C:53]1[S:57][C:56]([NH2:58])=[N:55][CH:54]=1)([CH3:51])[CH3:50])C>>[CH3:51][C:49]([S:52][C:53]1[S:57][C:56]([NH:58][C:12]([N:11]([C@H:25]2[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]2)[CH2:42][CH2:41][CH2:40][CH2:39][C:36]2[CH:35]=[CH:34][C:33]([CH3:32])=[CH:38][CH:37]=2)=[O:24])=[N:55][CH:54]=1)([CH3:50])[C:48]([OH:47])=[O:59]

Participants

4

Reactant 3

HCID 782794-p-Tolylbutyric acidHCID 57481427Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoateHCID 178461316HCID 178461316, compound

Product 1

HCID 178424961HCID 178424961, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of {2[-3-[3-(3-chloro-phenyl)-propyl]-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid using 4-(4-methyl-phenyl)-butyric-acid and 2-(2-amino-thiazol-5-ylsulfanyl)-2-methyl-propionic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-5432e57605e141b39157437a8a832a64
Source dataset
uspto-grants-2013_01
Patent number
US08362049B2

Reaction notes

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