4-(4-Methoxyphenyl)butyric acid → HCID 178490104, compound

HRID 1810090Notes

Reaction equation

HRID 1810090 reaction equation
ClC1C=C(CCC[N:11]([C@H:25]2[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]2)[C:12](=[O:24])NC2SC(SCC(O)=O)=CN=2)C=CC=1.[CH3:32][O:33][C:34]1[CH:39]=[CH:38][C:37]([CH2:40][CH2:41][CH2:42][C:43](O)=O)=[CH:36][CH:35]=1.C([O:48][C:49](=[O:60])[C:50]([S:53][C:54]1[S:58][C:57]([NH2:59])=[N:56][CH:55]=1)([CH3:52])[CH3:51])C>>[CH3:32][O:33][C:34]1[CH:35]=[CH:36][C:37]([CH2:40][CH2:41][CH2:42][CH2:43][N:11]([C@H:25]2[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]2)[C:12](=[O:24])[NH:59][C:57]2[S:58][C:54]([S:53][C:50]([CH3:51])([CH3:52])[C:49]([OH:48])=[O:60])=[CH:55][N:56]=2)=[CH:38][CH:39]=1

Participants

4

Reactant 3

HCID 782804-(4-Methoxyphenyl)butyric acidHCID 57481427Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoateHCID 178461316HCID 178461316, compound

Product 1

HCID 178490104HCID 178490104, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of {2-[-3-[3-(3-chloro-phenyl)-propyl]-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid using 4-(4-methoxy-phenyl)-butyric-acid and 2-(2-amino-thiazol-5-ylsulfanyl)-2-methyl-propionic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-c2805a595dfc469bbab5ffc45ab00cca
Source dataset
uspto-grants-2013_01
Patent number
US08362049B2

Reaction notes

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