4-Phenylbutyric Acid → HCID 178496614, compound

HRID 1810092Notes

Reaction equation

HRID 1810092 reaction equation
ClC1C=C([CH2:8][CH2:9][CH2:10][N:11]([C@H:25]2[CH2:30][CH2:29][C@H:28](C)[CH2:27][CH2:26]2)[C:12](=[O:24])[NH:13][C:14]2[S:15][C:16]([S:19][CH2:20][C:21]([OH:23])=[O:22])=[CH:17][N:18]=2)C=CC=1.[CH3:32][O:33][C@H]1CC[C@H](N)CC1.[C:41]1([CH2:47]CCC(O)=O)[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1.C(OC(=O)CSC1SC(N)=NC=1)C>>[CH3:32][O:33][C@H:28]1[CH2:29][CH2:30][C@H:25]([N:11]([CH2:10][CH2:9][CH2:8][CH2:47][C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)[C:12](=[O:24])[NH:13][C:14]2[S:15][C:16]([S:19][CH2:20][C:21]([OH:23])=[O:22])=[CH:17][N:18]=2)[CH2:26][CH2:27]1

Participants

5

Reactant 4

HCID 47754-Phenylbutyric AcidHCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 178461316HCID 178461316, compoundHCID 178496609HCID 178496609, compound

Product 1

HCID 178496614HCID 178496614, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of {2[-3-[3-(3-chloro-phenyl)-propyl]-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid using trans-4-methoxy-cyclohexylamine, 4-phenyl-butyric acid and (2-aminothiazol-5-ylsulfanyl)acetic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-34da52a9a0934a989d7fe628f967682d
Source dataset
uspto-grants-2013_01
Patent number
US08362049B2

Reaction notes

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