Potassium Carbonate → HCID 68510552, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of tert-butyl 2-(3-cyano-4-fluorophenyl)acetate (0.150 g, 0.6376 mmol) and N-(4-chlorophenethyl)-1H-indole-5carboxamide (0.2095 g, 0.7014 mmol) in DMSO (3 mL) was added K2CO3 (0.1322 g, 0.9564 mmol), and the reaction mixture was heated at 120° C. for 30 minutes, then at 130° C. for 1 hour. The reaction was diluted with ethyl acetate and the organic layer was washed with water and brine, dried over magnesium sulfate and concentrated. The residue was purified by silica gel chromatography eluting with a gradient of 5% to 100% ethyl acetate/hexanes to provide tert-butyl 2-(4-(5-((4-chlorophenethyl)carbamoyl)-1H-indol-1-yl)-3cyanophenyl)acetate (0.160 g, 48.82% yield) as a waxy solid. MS (APCI)=514.0 (M+1).

Provenance & Evidence