HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 1-(2-cyano-4-(2-methoxy-2-oxoethyl)phenyl)-1H-indole-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-butyl 1-(2-cyano-4-(2-methoxy-2-oxoethyl)phenyl)-1H-indole-5-carboxylate | HCID 68515072 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(2-cyano-4-(2-methoxy-2-oxoethyl)phenyl)-1H-indole-5-carboxylic acid | HCID 68512325 | 98% |
Reaction Steps
tert-butyl 1-(2-cyano-4-(2-methoxy-2-oxoethyl)phenyl)-1H-indole-5-carboxylate (0.380 g, 0.973 mmol, in 2 ml of DCM was added 2 mL of TFA and the reaction stirred at ambient temperature under nitrogen. After 2 hours, the reaction was concentrated to give 1-(2-cyano-4-(2-methoxy-2-oxoethyl)phenyl)-1H-indole-5-carboxylic acid (0.320 g, 0.957 mmol, 98%). MS (APCI negative)=333.2 (M−1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08362056B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-f211fd9739c547ff9759c6182a783014 |
| Source note | uspto-grants-2013_01 |