Pyridine → HCID 46700765, compound

HRID 1810116Notes

Reaction equation

HRID 1810116 reaction equation
[C:1]1([CH3:20])[CH:6]=[CH:5][C:4]([N:7]2[CH:11]=[C:10]([O:12][C:13]3[CH:18]=[CH:17][C:16]([NH2:19])=[CH:15][CH:14]=3)[CH:9]=[N:8]2)=[CH:3][CH:2]=1.[Cl:21][C:22]1[CH:27]=[C:26]([Cl:28])[CH:25]=[CH:24][C:23]=1[S:29](Cl)(=[O:31])=[O:30].N1C=CC=CC=1>C(Cl)(Cl)Cl>[Cl:21][C:22]1[CH:27]=[C:26]([Cl:28])[CH:25]=[CH:24][C:23]=1[S:29]([NH:19][C:16]1[CH:17]=[CH:18][C:13]([O:12][C:10]2[CH:9]=[N:8][N:7]([C:4]3[CH:3]=[CH:2][C:1]([CH3:20])=[CH:6][CH:5]=3)[CH:11]=2)=[CH:14][CH:15]=1)(=[O:31])=[O:30]

Participants

5

Reactant 3

HCID 1049PyridineHCID 204419Benzenesulfonyl chloride, 2,4-dichloro-HCID 66745571HCID 66745571, compound

Product 1

HCID 46700765HCID 46700765, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Conditions

Temperature
27.5 °C

Procedure

4-(1-p-Tolyl-1H-pyrazol-4-yloxy)-phenylamine (100 mg, 0754 mmol), 2,4 Dichloro-benzenesulfonyl chloride (92 mg, 0.754 mmol) was taken in chloroform and 0.2 ml of pyridine was added and the reaction mixture was stirred at 20-35° C. for 3 and half an hours. Chloroform was removed under vacuum and the product was purified though column chromatography using petroleum ether and ethyl acetate.

Workup

  1. customChloroform was removed under vacuum
  2. customthe product was purified though column chromatography

Sources & evidence

ORD record
ord-b6d80d355a21431e945029d9cb2f6696
Source dataset
uspto-grants-2013_01
Patent number
US08362064B2

Reaction notes

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