HCID 59364203, compound → HCID 59364223, compound

Participants

Reaction Steps

A solution of 222 (0.331 g, 0.748 mmol), crude 206 (0.42 g, 0.748 mmol), catalytic amount of CuI and tetrakis(triphenylphosphine)palladium in DMF (10 mL) was degassed with argon for 10 min (Scheme 16). The mixture was brought to 50° C. and stirred for 5 h. The solvent was removed in vacuo and the residue was purified by flash chromatography (20% ethyl acetate/hexane V:V) to yield 223 (0.22 g, 50%). 1H NMR (CDCl3): 2.36 (s, 3H), 2.38 (s, 3H), 7.26-7.33 (m, 5H), 7.43 (t, 1H. J=7.8), 7.56 (d, 1H, J=7.8), 7.80 (s, 1H), 7.84-7.87 (m, 4H), 7.92 (s, 1H), 8.11 (d, 1H, J=8.4), 8.17 (d, 1H, J=9.1), 8.28 (d, 1 H, J=9.0), 8.48 (s, 1H).

Provenance & Evidence