反应详情

To a suspension of 4-chloro-3-sulfamoyl-benzoic acid (50 g, 212 mmol) in 500 mL ethanol is bubbled HCl gas for 10 minutes. The resulting suspension is then heated at reflux for 16 h, cooled and concentrated in vacuo. The resulting residue is recrystallized from isopronanol to yield 55.9 g (99%) of the title compound as an off-white solid.

1. customis bubbled HCl gas for 10 minutes
2. temperatureThe resulting suspension is then heated
3. temperatureat reflux for 16 h
4. temperaturecooled
5. concentrationconcentrated in vacuo
6. customThe resulting residue is recrystallized from isopronanol